September 2026 Question
CHEST SEEK® Challenge: Which of the following is the most appropriate empiric antibiotic treatment regimen?

A 20-year-old woman presents to the emergency department with altered mental status. She is accompanied by a friend, who reports that the patient had a positive home pregnancy test 3 months ago but that she has not seen a health care provider in more than a year. Earlier today, the patient reported new pelvic pain; fever; and yellow, blood-tinged vaginal discharge.

In the emergency department, her vital signs are a BP of 85/40 mm Hg, pulse of 136/minute, respiratory rate of 27/minute, Sp₂ of 93% with a heated high-flow nasal cannula at FI₂ of 1.0, and temperature of 40.0 °C. Physical examination results are notable for a palpable uterine fundus with tenderness. Results of a speculum examination are notable for a linear laceration and dusky appearance of the cervix with thin, purulent fluid from the cervical os. Laboratory data are shown in Figure 1, and a chest radiograph is shown in Figure 2.

Figure 1. Laboratory values.

Figure 1. Laboratory values.

Figure 2. Chest radiograph

Figure 2. Chest radiograph.

 

 

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